Patri's Selegiline References Page

This page contains useful references to the drug Selegiline (Deprenyl) as used to slow aging in humans. I have tried not to include too many redundant and derivative websites, and to provide as wide a spectrum of viewpoints as can be found on the web, which is biased towards futurist/extropian/transhumanist types who are optimistic about the possibilities of technology. Keep in mind that some of the articles are by people who sell or promote anti-aging products.

• Individual Articles:
  • The following article from Colorado Futurescience was the only one that gave detailed warnings about possible oxidative side-effects of long-term deprenyl use and how to counteract them, and it seemed to know more about the worldwide history of the drug than the "generic" life-extension articles. It seems from internal evidence and my survey of the material that this is likely to be a worthwhile report.
  • Ward Dean's short intro to deprenyl on CERI.
  • CERI update on combination of Deprenyl & l-dopa which also mentions the anti-oxidant issues raised in the CFSC article above.
  • A longer Dean article.
  • BLTC's description of selegiline, with links.
  • LEF magazine article on dosages and effects.
  • Another LEF magazine article.
  • Basic description.
  • Good intro.
• A couple bigger sites:
  • Quality Counts lists deprenyl articles.
  • This is an introduction to deprenyl and some links.
• Academia: There are many PubMed abstracts of relevant scientific articles about selegiline.
  • References from selegiline.com.
  • References from the LEF organization.
  • Here is a large collection of PubMed abstracts that I picked.
• Contraindications: Here is one version and another version, of the package insert for Eldepryl.):
• Political: This site tells the story of the american company DEDI which invented the liquid form of deprenyl (selegiline citrate) and marketed it in the US. Because of pressure from the drug company which manufactures the standard form of deprenyl, the FDA and others busted DEDI, not only putting it out of business but putting its founder behind bars. There is moderate scientific and considerable anecdotal evidence that the citrate form is superior. It is now available from several other companies.
• Here is a good general life-extension webpage, which seemed less glitzy and full of promises to me than the sites which are associated with companies selling LEX drugs.
• Negative Sites (which were hard to find):
  • Dr. Tim Gorski's Healthy Skepticism (a negative piece on life-extension).
  • National Institute On Aging Age Page:Life Extension: Science or Science Fiction? (brief and not that informative).